The questions “Have you ever used Derbisol?” and “How often?” sometimes appear along with questions about alcohol, cocaine, and marijuana use on youth-risk surveys for students. Derbisol is a fictitious drug devised to test the reliability of the responder. In one survey, 163 of 894 students said that they had tried Derbisol—or 18.2 percent.

In his Brief Lives, John Aubrey wrote that in 1618 Walter Raleigh “took a pipe of tobacco a little before he went to the scaffold, which some formal persons were scandalized at, but I think ’twas well and properly done to settle his spirits.” Often credited with popularizing smoking in England, Raleigh was sentenced to death for treason by King James I, who had published his Counterblaste to Tobacco in 1604.