“I have absolutely no pleasure in the stimulants in which I sometimes so madly indulge. It has not been in the pursuit of pleasure that I have periled life and reputation and reason. It has been in the desperate attempt to escape from torturing memories,” wrote Edgar Allan Poe in a letter in the last year of his life.

Sent to suppress elements of Nathaniel Bacon’s Rebellion in 1676, British soldiers made a soup seasoned with Datura stramonium, a hallucinogen, “the effect of which,” as an eighteenth-century historian put it, “was a very pleasant comedy; for they turned natural fools upon it for several days; one would blow up a feather in the air, another would dart straws at it with much fury, and another, stark naked, was sitting up in a corner, like a monkey, grinning and making mows at them.” D. stramonium became known as jimson weed, named after Jamestown, Virginia, where the soldiers had been sent.