Isolated from opium by the German chemist F. W. A. Sertürner around 1804, morphine (named after Morpheus, the Greek god of sleep and dreams) was used to treat opium addicts. Invented by Bayer Pharmaceuticals in 1898, heroin (derived from the Greek word for hero) was used to treat morphine addicts.

In William Shakespeare’s Macbeth, Macduff asks the Porter, “What three things does drink especially provoke?” The Porter replies, “nose painting, sleep, and urine”—the first of which is usually taken to mean the red flush that comes across a drinker’s face. It also leads to lechery, the Porter says, adding, “it provokes the desire, but it takes away the performance.”