Overworked and suffering from chest and stomach conditions, Emperor Marcus Aurelius took a prescription from his physician, Galen, for opium. According to Galen, the emperor did not like that the drug made him drowsy, so he stopped taking it. Then he found himself unable to sleep, so he started taking it again.

In the United States around 1787—the year that Thomas Jefferson took a three-month sabbatical to tour the vineyards of France and Italy—the average drinking American consumed the equivalent of an estimated six gallons of pure alcohol per year. The figure today is 2.2.