Overworked and suffering from chest and stomach conditions, Emperor Marcus Aurelius took a prescription from his physician, Galen, for opium. According to Galen, the emperor did not like that the drug made him drowsy, so he stopped taking it. Then he found himself unable to sleep, so he started taking it again.

In his Brief Lives, John Aubrey wrote that in 1618 Walter Raleigh “took a pipe of tobacco a little before he went to the scaffold, which some formal persons were scandalized at, but I think ’twas well and properly done to settle his spirits.” Often credited with popularizing smoking in England, Raleigh was sentenced to death for treason by King James I, who had published his Counterblaste to Tobacco in 1604.