Isolated from opium by the German chemist F. W. A. Sertürner around 1804, morphine (named after Morpheus, the Greek god of sleep and dreams) was used to treat opium addicts. Invented by Bayer Pharmaceuticals in 1898, heroin (derived from the Greek word for hero) was used to treat morphine addicts.

In 1387 the physicians to Charles II of Navarre, in order to treat his illness, soaked his sheets in aqua vitae, a distilled wine, and wrapped him in them to enhance the curative power that the liquid was supposed to possess. The sheets were then sewn shut by a maid, who, instead of cutting the final bit of string, set a candle to it. The alcohol-soaked king went up in a blaze and the maid ran away, leaving him to burn to death.